Globular Adiponectin Limits Microglia Pro-Inflammatory Phenotype through an AdipoR1/NF-κB Signaling Pathway

Globular Adiponectin Limits Microglia Pro-Inflammatory Phenotype through an AdipoR1/NF-κB Signaling Pathway

We recently reported that increased levels of Adiponectin (ApN) in the brain led to microglia phenotype and activation state regulation, thus reducing both global brain inflammation and depressive-like behaviors in mice. Apart from this, little is known on ApN molecular effects on microglia, althoug...

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Bibliographic Details
Main Authors: Sarah Nicolas, Julie Cazareth, Hadi Zarif, Alice Guyon, Catherine Heurteaux, Joëlle Chabry, Agnès Petit-Paitel
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
microglia
astrocytes
brain
neuroinflammation
adipokines
cytokines
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00352/full

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