The Role of Hydrogen Peroxide in Environmental Adaptation of Oral Microbial Communities
Oral streptococci are able to produce growth-inhibiting amounts of hydrogen peroxide (H2O2) as byproduct of aerobic metabolism. Several recent studies showed that the produced H2O2 is not a simple byproduct of metabolism but functions in several aspects of oral bacterial biofilm ecology. First, the...
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Online Access: | http://dx.doi.org/10.1155/2012/717843 |
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doaj-3fdefb8abc1540f2933efadbd531bbb72020-11-24T22:46:49ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942012-01-01201210.1155/2012/717843717843The Role of Hydrogen Peroxide in Environmental Adaptation of Oral Microbial CommunitiesLin Zhu0Jens Kreth1Department of Periodontics, College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADepartment of Microbiology and Immunology, College of Medicine, University of Oklahoma Health Sciences Center, BMSB 907, 940 Stanton L Young Boulevard, Oklahoma City, OK 73104, USAOral streptococci are able to produce growth-inhibiting amounts of hydrogen peroxide (H2O2) as byproduct of aerobic metabolism. Several recent studies showed that the produced H2O2 is not a simple byproduct of metabolism but functions in several aspects of oral bacterial biofilm ecology. First, the release of DNA from cells is closely associated to the production of H2O2 in Streptococcus sanguinis and Streptococcus gordonii. Extracellular DNA is crucial for biofilm development and stabilization and can also serve as source for horizontal gene transfer between oral streptococci. Second, due to the growth inhibiting nature of H2O2, H2O2 compatible species associate with the producers. H2O2 production therefore might help in structuring the initial biofilm development. On the other hand, the oral environment harbors salivary peroxidases that are potent in H2O2 scavenging. Therefore, the effects of biofilm intrinsic H2O2 production might be locally confined. However, taking into account that 80% of initial oral biofilm constituents are streptococci, the influence of H2O2 on biofilm development and environmental adaptation might be under appreciated in current research.http://dx.doi.org/10.1155/2012/717843 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lin Zhu Jens Kreth |
spellingShingle |
Lin Zhu Jens Kreth The Role of Hydrogen Peroxide in Environmental Adaptation of Oral Microbial Communities Oxidative Medicine and Cellular Longevity |
author_facet |
Lin Zhu Jens Kreth |
author_sort |
Lin Zhu |
title |
The Role of Hydrogen Peroxide in Environmental Adaptation of Oral Microbial Communities |
title_short |
The Role of Hydrogen Peroxide in Environmental Adaptation of Oral Microbial Communities |
title_full |
The Role of Hydrogen Peroxide in Environmental Adaptation of Oral Microbial Communities |
title_fullStr |
The Role of Hydrogen Peroxide in Environmental Adaptation of Oral Microbial Communities |
title_full_unstemmed |
The Role of Hydrogen Peroxide in Environmental Adaptation of Oral Microbial Communities |
title_sort |
role of hydrogen peroxide in environmental adaptation of oral microbial communities |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2012-01-01 |
description |
Oral streptococci are able to produce growth-inhibiting amounts of hydrogen peroxide (H2O2) as byproduct of aerobic metabolism. Several recent studies showed that the produced H2O2 is not a simple byproduct of metabolism but functions in several aspects of oral bacterial biofilm ecology. First, the release of DNA from cells is closely associated to the production of H2O2 in Streptococcus sanguinis and Streptococcus gordonii. Extracellular DNA is crucial for biofilm development and stabilization and can also serve as source for horizontal gene transfer between oral streptococci. Second, due to the growth inhibiting nature of H2O2, H2O2 compatible species associate with the producers. H2O2 production therefore might help in structuring the initial biofilm development. On the other hand, the oral environment harbors salivary peroxidases that are potent in H2O2 scavenging. Therefore, the effects of biofilm intrinsic H2O2 production might be locally confined. However, taking into account that 80% of initial oral biofilm constituents are streptococci, the influence of H2O2 on biofilm development and environmental adaptation might be under appreciated in current research. |
url |
http://dx.doi.org/10.1155/2012/717843 |
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