Impact of diffusion barriers to small cytotoxic molecules on the efficacy of immunotherapy in breast cancer.

Impact of diffusion barriers to small cytotoxic molecules on the efficacy of immunotherapy in breast cancer.

Molecular-focused cancer therapies, e.g., molecularly targeted therapy and immunotherapy, so far demonstrate only limited efficacy in cancer patients. We hypothesize that underestimating the role of biophysical factors that impact the delivery of drugs or cytotoxic cells to the target sites (for ass...

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Bibliographic Details
Main Authors: Hiranmoy Das, Zhihui Wang, M Khalid Khan Niazi, Reeva Aggarwal, Jingwei Lu, Suman Kanji, Manjusri Das, Matthew Joseph, Metin Gurcan, Vittorio Cristini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3631240?pdf=render

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