Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders

Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders

Vogt-Koyanagi-Harada syndrome (VKH) and vitiligo are autoimmune diseases that target melanocytes. VKH affects several organs such as the skin, hair follicle, eyes, ears, and meninges, whereas vitiligo is often limited to the skin and mucosa. Many studies have identified immune genes, pathways and ce...

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Bibliographic Details
Main Authors: Ista A. Egbeto, Colton J. Garelli, Cesar Piedra-Mora, Neil B. Wong, Clement N. David, Nicholas A. Robinson, Jillian M. Richmond
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
vitiligo
Vogt-Koyanagi-Harada disease
immunopathogenesis
transcriptomics
comparative immunology
canine (dog)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.590558/full

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