Pellitorine, a Potential Anti-Cancer Lead Compound against HL60 and MCT-7 Cell Lines and Microbial Transformation of Piperine from Piper Nigrum

Pellitorine, a Potential Anti-Cancer Lead Compound against HL60 and MCT-7 Cell Lines and Microbial Transformation of Piperine from Piper Nigrum

Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Pi...

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Bibliographic Details
Main Authors: Gwendoline Cheng Lian Ee, Chyi Meei Lim, Mawardi Rahmani, Khozirah Shaari, Choon Fah Joseph Bong
Format: Article
Language:English
Published: MDPI AG 2010-04-01
Series:Molecules
Subjects:
Piper nigrum
pellitorine
alkaloids
cytotoxicity
microbial transformation
aspergillus niger
Online Access:http://www.mdpi.com/1420-3049/15/4/2398/
Description
Summary:Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Piper nigrum. They are (E)-1-[3’,4’-(methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). These compounds were isolated using chromatographic methods and their structures were elucidated using MS, IR and NMR techniques.
ISSN:1420-3049

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