Synthesis of New C2- Symmetric Fluoren-9-ylidene Malonate Derived Bis(oxazoline) Ligands and Their Application in Friedel-Crafts Reactions
A series of new C2-symmetric fluoren-9-ylidene malonate-derived bis(oxazoline) ligands were synthesized from fluoren-9-ylidene malonate and enantiomerically pure amino alcohols via a convenient route. Their asymmetric catalytic properties in the Friedel-Crafts reactions of indoles with arylidene mal...
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MDPI AG
2010-11-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/15/12/8582/ |
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doaj-3fb44fa2037f45429e748863cd9070772020-11-24T22:20:56ZengMDPI AGMolecules1420-30492010-11-0115128582859210.3390/molecules15128582Synthesis of New C2- Symmetric Fluoren-9-ylidene Malonate Derived Bis(oxazoline) Ligands and Their Application in Friedel-Crafts ReactionsLei LiuBin FuJing LiHong-Liang ChenA series of new C2-symmetric fluoren-9-ylidene malonate-derived bis(oxazoline) ligands were synthesized from fluoren-9-ylidene malonate and enantiomerically pure amino alcohols via a convenient route. Their asymmetric catalytic properties in the Friedel-Crafts reactions of indoles with arylidene malonates were evaluated, and the Cu(OTf)2 complex of a fluoren-9-ylidene malonate-derived bis(oxazoline) bearing a phenyl group showed moderate to good enantioselectivity (up to 88% ee). http://www.mdpi.com/1420-3049/15/12/8582/bis(oxazoline)fluoren-9-ylideneasymmetric catalysisFriedel-Crafts |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Lei Liu Bin Fu Jing Li Hong-Liang Chen |
| spellingShingle |
Lei Liu Bin Fu Jing Li Hong-Liang Chen Synthesis of New C2- Symmetric Fluoren-9-ylidene Malonate Derived Bis(oxazoline) Ligands and Their Application in Friedel-Crafts Reactions Molecules bis(oxazoline) fluoren-9-ylidene asymmetric catalysis Friedel-Crafts |
| author_facet |
Lei Liu Bin Fu Jing Li Hong-Liang Chen |
| author_sort |
Lei Liu |
| title |
Synthesis of New C2- Symmetric Fluoren-9-ylidene Malonate Derived Bis(oxazoline) Ligands and Their Application in Friedel-Crafts Reactions |
| title_short |
Synthesis of New C2- Symmetric Fluoren-9-ylidene Malonate Derived Bis(oxazoline) Ligands and Their Application in Friedel-Crafts Reactions |
| title_full |
Synthesis of New C2- Symmetric Fluoren-9-ylidene Malonate Derived Bis(oxazoline) Ligands and Their Application in Friedel-Crafts Reactions |
| title_fullStr |
Synthesis of New C2- Symmetric Fluoren-9-ylidene Malonate Derived Bis(oxazoline) Ligands and Their Application in Friedel-Crafts Reactions |
| title_full_unstemmed |
Synthesis of New C2- Symmetric Fluoren-9-ylidene Malonate Derived Bis(oxazoline) Ligands and Their Application in Friedel-Crafts Reactions |
| title_sort |
synthesis of new c2- symmetric fluoren-9-ylidene malonate derived bis(oxazoline) ligands and their application in friedel-crafts reactions |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2010-11-01 |
| description |
A series of new C2-symmetric fluoren-9-ylidene malonate-derived bis(oxazoline) ligands were synthesized from fluoren-9-ylidene malonate and enantiomerically pure amino alcohols via a convenient route. Their asymmetric catalytic properties in the Friedel-Crafts reactions of indoles with arylidene malonates were evaluated, and the Cu(OTf)2 complex of a fluoren-9-ylidene malonate-derived bis(oxazoline) bearing a phenyl group showed moderate to good enantioselectivity (up to 88% ee). |
| topic |
bis(oxazoline) fluoren-9-ylidene asymmetric catalysis Friedel-Crafts |
| url |
http://www.mdpi.com/1420-3049/15/12/8582/ |
| work_keys_str_mv |
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