A miniature multi-contrast microscope for functional imaging in freely behaving animals

Measuring multiple neurophysiologic variables usually requires bulky benchtop optical systems and working with anesthetized animals. Here the authors present a miniature portable microscope for neurovascular imaging in awake rodents, combining fluorescence, intrinsic optical signals and laser speckl...

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Bibliographic Details
Main Authors: Janaka Senarathna, Hang Yu, Callie Deng, Alice L. Zou, John B. Issa, Darian H. Hadjiabadi, Stacy Gil, Qihong Wang, Betty M. Tyler, Nitish V. Thakor, Arvind P. Pathak
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07926-z
Description
Summary:Measuring multiple neurophysiologic variables usually requires bulky benchtop optical systems and working with anesthetized animals. Here the authors present a miniature portable microscope for neurovascular imaging in awake rodents, combining fluorescence, intrinsic optical signals and laser speckle contrast.
ISSN:2041-1723