Chronic myeloid leukemia following nasopharyngeal carcinoma
We describe a case of 48 year old woman with chronic myeloid leukemia (CML) occurring 13 years after a nasopharyngeal carcinoma treated with chemotherapy and radiotherapy. Bone marrow cytogenetic study demonstrated the presence of the t(9.22) and the molecular biology study showed rearrangement b2a...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1914 |
| Summary: | We describe a case of 48 year old woman with chronic myeloid leukemia (CML) occurring 13 years after a nasopharyngeal carcinoma treated with chemotherapy and radiotherapy. Bone marrow cytogenetic study demonstrated the presence of the t(9.22) and the molecular biology study showed rearrangement b2a2. She was managed with tyrosine kinase inhibitor but she died in blastic crisis. This case supports the observation that CML can develop as an important late complication after chemo and radiotherapy.
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| ISSN: | 2035-3006 |