Hair-Growth-Promoting Effects of Fermented Red Ginseng Marc and Traditional Polyherb Formula in C57BL/6 Mice

An abnormal hair-growth cycle induces hair loss, which affects psychological distress and impairs life quality. Red ginseng marc (RGM) is usually discarded as a byproduct after extracting red ginseng, but several studies have shown that the RGM still has bioactive components including ginsenosides....

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Main Authors: Phil Hyun Song, Gyu-Ryeul Park, Yoon-Hae Kim, Dae Hwa Jung, Sae-Kwang Ku, Chang-Hyun Song
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Applied Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3417/11/3/1195
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spelling doaj-3f91108cf52244f798073caeebf7009a2021-01-29T00:02:04ZengMDPI AGApplied Sciences2076-34172021-01-01111195119510.3390/app11031195Hair-Growth-Promoting Effects of Fermented Red Ginseng Marc and Traditional Polyherb Formula in C57BL/6 MicePhil Hyun Song0Gyu-Ryeul Park1Yoon-Hae Kim2Dae Hwa Jung3Sae-Kwang Ku4Chang-Hyun Song5Department of Urology, College of Medicine, Yeungnam University, Daegu 42415, KoreaDepartment of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, KoreaPung-gi Ginseng Production Farming Cooperation, Yeongju 689822, KoreaDepartment of Pharmaceutical Engineering, Daegu Haany University, Gyeongsan 38610, KoreaDepartment of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, KoreaDepartment of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, KoreaAn abnormal hair-growth cycle induces hair loss, which affects psychological distress and impairs life quality. Red ginseng marc (RGM) is usually discarded as a byproduct after extracting red ginseng, but several studies have shown that the RGM still has bioactive components including ginsenosides. Therefore, the hair-growth effects of fermented RGM (fRGM) and traditional polyherb formula (PH) were examined in C57BL/6 mice. The dorsal hairs of mice were depilated, and they were topically treated with fRGM or PH at 400, 200 and 100 mg/kg or the combination of both middle doses (combi) once a day for two weeks. The hair-covering regions were significantly increased with higher doses of fRGM and PH and in combi groups, compared with the control treated with distilled water. Hair length, thickness and weight also increased in the treatment groups. In particular, the fRGM and PH increased the anagen-phased hair follicles, the follicular diameters and the dermal thickness. Immunostains for Ki-67 showed the anagen-phased cell division in the treatment groups. The beneficial effects were greater in the high doses of fRGM and PH and the combi groups. These suggest hair-growth-promoting effects of fRGM, PH and the combination by enhancing the hair-growth cycle.https://www.mdpi.com/2076-3417/11/3/1195hair growthgrowth cyclered ginseng marcpolyherbhair lengthhair thickness
collection DOAJ
language English
format Article
sources DOAJ
author Phil Hyun Song
Gyu-Ryeul Park
Yoon-Hae Kim
Dae Hwa Jung
Sae-Kwang Ku
Chang-Hyun Song
spellingShingle Phil Hyun Song
Gyu-Ryeul Park
Yoon-Hae Kim
Dae Hwa Jung
Sae-Kwang Ku
Chang-Hyun Song
Hair-Growth-Promoting Effects of Fermented Red Ginseng Marc and Traditional Polyherb Formula in C57BL/6 Mice
Applied Sciences
hair growth
growth cycle
red ginseng marc
polyherb
hair length
hair thickness
author_facet Phil Hyun Song
Gyu-Ryeul Park
Yoon-Hae Kim
Dae Hwa Jung
Sae-Kwang Ku
Chang-Hyun Song
author_sort Phil Hyun Song
title Hair-Growth-Promoting Effects of Fermented Red Ginseng Marc and Traditional Polyherb Formula in C57BL/6 Mice
title_short Hair-Growth-Promoting Effects of Fermented Red Ginseng Marc and Traditional Polyherb Formula in C57BL/6 Mice
title_full Hair-Growth-Promoting Effects of Fermented Red Ginseng Marc and Traditional Polyherb Formula in C57BL/6 Mice
title_fullStr Hair-Growth-Promoting Effects of Fermented Red Ginseng Marc and Traditional Polyherb Formula in C57BL/6 Mice
title_full_unstemmed Hair-Growth-Promoting Effects of Fermented Red Ginseng Marc and Traditional Polyherb Formula in C57BL/6 Mice
title_sort hair-growth-promoting effects of fermented red ginseng marc and traditional polyherb formula in c57bl/6 mice
publisher MDPI AG
series Applied Sciences
issn 2076-3417
publishDate 2021-01-01
description An abnormal hair-growth cycle induces hair loss, which affects psychological distress and impairs life quality. Red ginseng marc (RGM) is usually discarded as a byproduct after extracting red ginseng, but several studies have shown that the RGM still has bioactive components including ginsenosides. Therefore, the hair-growth effects of fermented RGM (fRGM) and traditional polyherb formula (PH) were examined in C57BL/6 mice. The dorsal hairs of mice were depilated, and they were topically treated with fRGM or PH at 400, 200 and 100 mg/kg or the combination of both middle doses (combi) once a day for two weeks. The hair-covering regions were significantly increased with higher doses of fRGM and PH and in combi groups, compared with the control treated with distilled water. Hair length, thickness and weight also increased in the treatment groups. In particular, the fRGM and PH increased the anagen-phased hair follicles, the follicular diameters and the dermal thickness. Immunostains for Ki-67 showed the anagen-phased cell division in the treatment groups. The beneficial effects were greater in the high doses of fRGM and PH and the combi groups. These suggest hair-growth-promoting effects of fRGM, PH and the combination by enhancing the hair-growth cycle.
topic hair growth
growth cycle
red ginseng marc
polyherb
hair length
hair thickness
url https://www.mdpi.com/2076-3417/11/3/1195
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