Prostate cancer induced by loss of Apc is restrained by TGFβ signaling.

Prostate cancer induced by loss of Apc is restrained by TGFβ signaling.

Recent work with mouse models of prostate cancer (CaP) has shown that inactivation of TGFβ signaling in prostate epithelium can cooperate with deletion of the Pten tumor suppressor to drive locally aggressive cancer and metastatic disease. Here, we show that inactivating the TGFβ pathway by deleting...

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Bibliographic Details
Main Authors: Glen A Bjerke, Karolina Pietrzak, Tiffany A Melhuish, Henry F Frierson, Bryce M Paschal, David Wotton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3961420?pdf=render

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