Identification of a WNT5A-Responsive Degradation Domain in the Kinesin Superfamily Protein KIF26B

Identification of a WNT5A-Responsive Degradation Domain in the Kinesin Superfamily Protein KIF26B

Noncanonical WNT pathways function independently of the β-catenin transcriptional co-activator to regulate diverse morphogenetic and pathogenic processes. Recent studies showed that noncanonical WNTs, such as WNT5A, can signal the degradation of several downstream effectors, thereby modulating these...

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Bibliographic Details
Main Authors: Edith P. Karuna, Shannon S. Choi, Michael K. Scales, Jennie Hum, Michael Cohen, Fernando A. Fierro, Hsin-Yi Henry Ho
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Genes
Subjects:
WNT5A
KIF26B
ROR receptors
Frizzled receptors
Dishevelled
GSK3
protein degradation
mesenchymal stem cells
Online Access:http://www.mdpi.com/2073-4425/9/4/196

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