Metabolism of coprostanol-C14 and cholestanol-4-C14 in man

• Main Authors: R.S. Rosenfeld, Barnett Zumoff, Leon Hellman
• Format: Article
• Language: English
• Published: Elsevier 1963-07-01
• Series: Journal of Lipid Research
• Online Access: http://www.sciencedirect.com/science/article/pii/S0022227520403116

Coprostanol-C14, biosynthetically prepared, was administered orally to two patients, and cholestanol-4-C14 was administered to one of them 10 months later. At the time when radioactivity in the circulation was at a maximum, 3.6 and 3.5% of the administered labeled coprostanol was present in the plasma; the corresponding value after administration of cholestanol-C14 was 4.7%. The dynamic behavior of absorbed radioactive cholestanol was identical with that of orally ingested cholesterol-4-C14, including the esterification process; on the other hand, virtually no coprostanol ester was present in the circulation. It is suggested that the conformation of the A/B rings or configuration at C-3 are related to the esterification mechanism of sterols. After 5 days, over 50% of both compounds had been excreted in the feces. The conversion of coprostanol-C14 to coprostanone-C14 has been demonstrated.