Interplay of Autophagy Inducer Rapamycin and Proteasome Inhibitor MG132 in Reduction of Foam Cell Formation and Inflammatory Cytokine Expression

MG132 is a pivotal inhibitor of the ubiquitin-proteasome system (UPS), and rapamycin (RAPA) is an important inducer of autophagy. MG132 and RAPA have been shown to be effective agents that can cure multiple autoimmune diseases by reducing inflammation. Although individual MG132 and RAPA showed prote...

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Bibliographic Details
Main Authors: Wei Zhang, Wan Xu, Wenli Chen, Quan Zhou
Format: Article
Language:English
Published: SAGE Publishing 2018-08-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/0963689718786229