Treatment with 1,25(OH)2D3 induced HDAC2 expression and reduced NF-κB p65 expression in a rat model of OVA-induced asthma

Treatment with 1,25(OH)2D3 induced HDAC2 expression and reduced NF-κB p65 expression in a rat model of OVA-induced asthma

Recent evidence indicates that a deficiency of 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) may influence asthma pathogenesis; however, its roles in regulating specific molecular transcription mechanisms remain unclear. We aimed to investigate the effect of 1,25(OH)2D3 on the expression and enzyme activit...

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Bibliographic Details
Main Authors: Y. Zhou, G.F. Wang, L. Yang, F. Liu, J.Q. Kang, R.L. Wang, W. Gu, C.Y. Wang
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2015-07-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
1,25-Dihydroxyvitamin D3
Asthma
Acetylation
Deacetylation
Histone deacetylase 2
NF-κB
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000700654&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000700654&lng=en&tlng=en

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