CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS

CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS

Аbstract. The aim of present study was to investigate an influence of polyclonal activators upon cytokine-producing function of peripheral blood cells in the patients with colorectal adenocarcinomas. It was revealed that the stimulated production of IL-1β, IL-1ra, IL-2, IL-17, IL-18 and IFNγ by whol...

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Main Authors: A. V. Sosnina, A. I. Autenshlyus, N. V. Velikaya, N. A. Varaksin, M. Yu. Rukhavishnikov, E. S. Mikhailova, D. V. Morozov, S. A. Fursov, N. V. Agarina
Format: Article
Language:Russian
Published: SPb RAACI 2014-07-01
Series:Medicinskaâ Immunologiâ
Subjects:
cytokines
polyclonal activators
colorectal cancera
Online Access:https://www.mimmun.ru/mimmun/article/view/519
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spelling doaj-3f70631f593e47abb394e9ed784d1edf2021-07-29T09:02:26ZrusSPb RAACIMedicinskaâ Immunologiâ1563-06252313-741X2014-07-01132-319720410.15789/1563-0625-2011-2-3-197-204516CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTSA. V. Sosnina0A. I. Autenshlyus1N. V. VelikayaN. A. Varaksin2M. Yu. Rukhavishnikov3E. S. Mikhailova4D. V. Morozov5S. A. Fursov6N. V. Agarina7НИИ молекулярной биологии и биофизики СО РАМН, г. НовосибирскНИИ молекулярной биологии и биофизики СО РАМН, г. НовосибирскЗАО «Вектор-Бест», г. НовосибирскЗАО «Вектор-Бест», г. НовосибирскНИИ молекулярной биологии и биофизики СО РАМН, г. НовосибирскНИИ молекулярной биологии и биофизики СО РАМН, г. НовосибирскНовосибирский областной онкологический диспансер, г. НовосибирскНовосибирский областной онкологический диспансер, г. НовосибирскАbstract. The aim of present study was to investigate an influence of polyclonal activators upon cytokine-producing function of peripheral blood cells in the patients with colorectal adenocarcinomas. It was revealed that the stimulated production of IL-1β, IL-1ra, IL-2, IL-17, IL-18 and IFNγ by whole blood cells treated with polyclonal activators was significantly decreased in colorectal cancer patients, as compared to healthy individuals. The stimulated IL-1ra and IL-17 production was depressed during the tumor progression, along with increased release of TNFα and IL-8. It was found that the stimulation index of polyclonal activators upon production of IL-17 by whole blood cells (i.e., a cytokine production ratio of stimulated versus resting cells) may be used as a reliable pre-surgery predictor of tumor invasion, the latter being an important histopathological parameter for clinical oncologists. (Med. Immunol., 2011, vol. 13, N 2-3, pp 197-204https://www.mimmun.ru/mimmun/article/view/519cytokinespolyclonal activatorscolorectal cancera
collection DOAJ
language Russian
format Article
sources DOAJ
author A. V. Sosnina
A. I. Autenshlyus
N. V. Velikaya
N. A. Varaksin
M. Yu. Rukhavishnikov
E. S. Mikhailova
D. V. Morozov
S. A. Fursov
N. V. Agarina
spellingShingle A. V. Sosnina
A. I. Autenshlyus
N. V. Velikaya
N. A. Varaksin
M. Yu. Rukhavishnikov
E. S. Mikhailova
D. V. Morozov
S. A. Fursov
N. V. Agarina
CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS
Medicinskaâ Immunologiâ
cytokines
polyclonal activators
colorectal cancera
author_facet A. V. Sosnina
A. I. Autenshlyus
N. V. Velikaya
N. A. Varaksin
M. Yu. Rukhavishnikov
E. S. Mikhailova
D. V. Morozov
S. A. Fursov
N. V. Agarina
author_sort A. V. Sosnina
title CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS
title_short CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS
title_full CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS
title_fullStr CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS
title_full_unstemmed CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS
title_sort cytokine-producing function of peripheral blood cells in colorectal cancer patients
publisher SPb RAACI
series Medicinskaâ Immunologiâ
issn 1563-0625
2313-741X
publishDate 2014-07-01
description Аbstract. The aim of present study was to investigate an influence of polyclonal activators upon cytokine-producing function of peripheral blood cells in the patients with colorectal adenocarcinomas. It was revealed that the stimulated production of IL-1β, IL-1ra, IL-2, IL-17, IL-18 and IFNγ by whole blood cells treated with polyclonal activators was significantly decreased in colorectal cancer patients, as compared to healthy individuals. The stimulated IL-1ra and IL-17 production was depressed during the tumor progression, along with increased release of TNFα and IL-8. It was found that the stimulation index of polyclonal activators upon production of IL-17 by whole blood cells (i.e., a cytokine production ratio of stimulated versus resting cells) may be used as a reliable pre-surgery predictor of tumor invasion, the latter being an important histopathological parameter for clinical oncologists. (Med. Immunol., 2011, vol. 13, N 2-3, pp 197-204
topic cytokines
polyclonal activators
colorectal cancera
url https://www.mimmun.ru/mimmun/article/view/519
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AT aiautenshlyus cytokineproducingfunctionofperipheralbloodcellsincolorectalcancerpatients
AT nvvelikaya cytokineproducingfunctionofperipheralbloodcellsincolorectalcancerpatients
AT navaraksin cytokineproducingfunctionofperipheralbloodcellsincolorectalcancerpatients
AT myurukhavishnikov cytokineproducingfunctionofperipheralbloodcellsincolorectalcancerpatients
AT esmikhailova cytokineproducingfunctionofperipheralbloodcellsincolorectalcancerpatients
AT dvmorozov cytokineproducingfunctionofperipheralbloodcellsincolorectalcancerpatients
AT safursov cytokineproducingfunctionofperipheralbloodcellsincolorectalcancerpatients
AT nvagarina cytokineproducingfunctionofperipheralbloodcellsincolorectalcancerpatients
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