Physicochemical Characterization and Biocompatibility of SPION@Plasmonic @Chitosan Core-Shell Nanocomposite Biosynthesized from Fungus Species

Physicochemical Characterization and Biocompatibility of SPION@Plasmonic @Chitosan Core-Shell Nanocomposite Biosynthesized from Fungus Species

In this work we aim to manipulate green route for the synthesis of core-shell maghemite-based Ag nanoparticles functionalized with chitosan. Three fungal species, Aspergillus deflectus, Fusarium oxysporum, and Penicillium pinophilum, were used in the process of synthesis to select the best among the...

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Main Authors: M. M. Eid, S. M. El-Hallouty, M. El-Manawaty, F. H. Abdelzaher
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Journal of Nanomaterials
Online Access:http://dx.doi.org/10.1155/2019/4024958
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spelling doaj-3f5c2ddd8d854ede8f93388baf4b9e022020-11-24T21:56:46ZengHindawi LimitedJournal of Nanomaterials1687-41101687-41292019-01-01201910.1155/2019/40249584024958Physicochemical Characterization and Biocompatibility of SPION@Plasmonic @Chitosan Core-Shell Nanocomposite Biosynthesized from Fungus SpeciesM. M. Eid0S. M. El-Hallouty1M. El-Manawaty2F. H. Abdelzaher3Spectroscopy Department, National Research Centre, Dokki, Giza, EgyptPharmacognosy Department, National Research Centre, Dokki, Giza, EgyptPharmacognosy Department, National Research Centre, Dokki, Giza, EgyptMicrobiology Department, National Research Centre, Dokki, Giza, EgyptIn this work we aim to manipulate green route for the synthesis of core-shell maghemite-based Ag nanoparticles functionalized with chitosan. Three fungal species, Aspergillus deflectus, Fusarium oxysporum, and Penicillium pinophilum, were used in the process of synthesis to select the best among them for the production. The physicochemical parameters of produced nanoparticles and mediated cytotoxicity assessment for their potential medical application have been performed using Fourier transform infrared (FTIR), UV/visible, vibrating sample magnetometer (VSM), dynamic light scattering (DLS), high-resolution transmission electron microscope (HRTEM), EDAX, and MTT to plot a cytotoxicity assessment report. The results confirmed the formation of monodispersed γFe2O3@Ag@chitosan with low cytotoxicity against prostate (PC3), liver (HepG2), column (HCT116), and breast cancer (MCF7) ATCC cell lines. In conclusion, these results prove the success of the green route used for the biosynthesis of γFe2O3@Ag@chitosan with parameters necessary for bioimaging, drug and gene delivery, and biosensing.http://dx.doi.org/10.1155/2019/4024958
collection DOAJ
language English
format Article
sources DOAJ
author M. M. Eid
S. M. El-Hallouty
M. El-Manawaty
F. H. Abdelzaher
spellingShingle M. M. Eid
S. M. El-Hallouty
M. El-Manawaty
F. H. Abdelzaher
Physicochemical Characterization and Biocompatibility of SPION@Plasmonic @Chitosan Core-Shell Nanocomposite Biosynthesized from Fungus Species
Journal of Nanomaterials
author_facet M. M. Eid
S. M. El-Hallouty
M. El-Manawaty
F. H. Abdelzaher
author_sort M. M. Eid
title Physicochemical Characterization and Biocompatibility of SPION@Plasmonic @Chitosan Core-Shell Nanocomposite Biosynthesized from Fungus Species
title_short Physicochemical Characterization and Biocompatibility of SPION@Plasmonic @Chitosan Core-Shell Nanocomposite Biosynthesized from Fungus Species
title_full Physicochemical Characterization and Biocompatibility of SPION@Plasmonic @Chitosan Core-Shell Nanocomposite Biosynthesized from Fungus Species
title_fullStr Physicochemical Characterization and Biocompatibility of SPION@Plasmonic @Chitosan Core-Shell Nanocomposite Biosynthesized from Fungus Species
title_full_unstemmed Physicochemical Characterization and Biocompatibility of SPION@Plasmonic @Chitosan Core-Shell Nanocomposite Biosynthesized from Fungus Species
title_sort physicochemical characterization and biocompatibility of spion@plasmonic @chitosan core-shell nanocomposite biosynthesized from fungus species
publisher Hindawi Limited
series Journal of Nanomaterials
issn 1687-4110
1687-4129
publishDate 2019-01-01
description In this work we aim to manipulate green route for the synthesis of core-shell maghemite-based Ag nanoparticles functionalized with chitosan. Three fungal species, Aspergillus deflectus, Fusarium oxysporum, and Penicillium pinophilum, were used in the process of synthesis to select the best among them for the production. The physicochemical parameters of produced nanoparticles and mediated cytotoxicity assessment for their potential medical application have been performed using Fourier transform infrared (FTIR), UV/visible, vibrating sample magnetometer (VSM), dynamic light scattering (DLS), high-resolution transmission electron microscope (HRTEM), EDAX, and MTT to plot a cytotoxicity assessment report. The results confirmed the formation of monodispersed γFe2O3@Ag@chitosan with low cytotoxicity against prostate (PC3), liver (HepG2), column (HCT116), and breast cancer (MCF7) ATCC cell lines. In conclusion, these results prove the success of the green route used for the biosynthesis of γFe2O3@Ag@chitosan with parameters necessary for bioimaging, drug and gene delivery, and biosensing.
url http://dx.doi.org/10.1155/2019/4024958
work_keys_str_mv AT mmeid physicochemicalcharacterizationandbiocompatibilityofspionplasmonicchitosancoreshellnanocompositebiosynthesizedfromfungusspecies
AT smelhallouty physicochemicalcharacterizationandbiocompatibilityofspionplasmonicchitosancoreshellnanocompositebiosynthesizedfromfungusspecies
AT melmanawaty physicochemicalcharacterizationandbiocompatibilityofspionplasmonicchitosancoreshellnanocompositebiosynthesizedfromfungusspecies
AT fhabdelzaher physicochemicalcharacterizationandbiocompatibilityofspionplasmonicchitosancoreshellnanocompositebiosynthesizedfromfungusspecies
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