A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61

Varicella-zoster virus (VZV) establishes lifelong infection in the majority of the population, but mechanisms underlying latency remain unclear. Here, the authors use ultra-deep RNA sequencing, enriched for viral RNAs, of latently infected human trigeminal ganglia and identify a spliced, latency-ass...

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Main Authors:	Daniel P. Depledge, Werner J. D. Ouwendijk, Tomohiko Sadaoka, Shirley E. Braspenning, Yasuko Mori, Randall J. Cohrs, Georges M. G. M. Verjans, Judith Breuer
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03569-2

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spelling	doaj-3f51ee80bfab464b894f8be32f3866ef2021-05-11T09:53:33ZengNature Publishing GroupNature Communications2041-17232018-03-019111210.1038/s41467-018-03569-2A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61Daniel P. Depledge0Werner J. D. Ouwendijk1Tomohiko Sadaoka2Shirley E. Braspenning3Yasuko Mori4Randall J. Cohrs5Georges M. G. M. Verjans6Judith Breuer7Division of Infection and Immunity, University College LondonDepartment of Viroscience, Erasmus Medical CentreDivision of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of MedicineDepartment of Viroscience, Erasmus Medical CentreDivision of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of MedicineDepartment of Neurology, University of Colorado School of MedicineDepartment of Viroscience, Erasmus Medical CentreDivision of Infection and Immunity, University College LondonVaricella-zoster virus (VZV) establishes lifelong infection in the majority of the population, but mechanisms underlying latency remain unclear. Here, the authors use ultra-deep RNA sequencing, enriched for viral RNAs, of latently infected human trigeminal ganglia and identify a spliced, latency-associated VZV mRNA.https://doi.org/10.1038/s41467-018-03569-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Daniel P. Depledge Werner J. D. Ouwendijk Tomohiko Sadaoka Shirley E. Braspenning Yasuko Mori Randall J. Cohrs Georges M. G. M. Verjans Judith Breuer
spellingShingle	Daniel P. Depledge Werner J. D. Ouwendijk Tomohiko Sadaoka Shirley E. Braspenning Yasuko Mori Randall J. Cohrs Georges M. G. M. Verjans Judith Breuer A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61 Nature Communications
author_facet	Daniel P. Depledge Werner J. D. Ouwendijk Tomohiko Sadaoka Shirley E. Braspenning Yasuko Mori Randall J. Cohrs Georges M. G. M. Verjans Judith Breuer
author_sort	Daniel P. Depledge
title	A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61
title_short	A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61
title_full	A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61
title_fullStr	A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61
title_full_unstemmed	A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61
title_sort	spliced latency-associated vzv transcript maps antisense to the viral transactivator gene 61
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-03-01
description	Varicella-zoster virus (VZV) establishes lifelong infection in the majority of the population, but mechanisms underlying latency remain unclear. Here, the authors use ultra-deep RNA sequencing, enriched for viral RNAs, of latently infected human trigeminal ganglia and identify a spliced, latency-associated VZV mRNA.
url	https://doi.org/10.1038/s41467-018-03569-2
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A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61

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