Anticancer Drug-Induced Epithelial-Mesenchymal Transition via p53/miR-34a axis in A549/ABCA3 Cells

PURPOSE. Several anticancer drugs including bleomycin (BLM) and methotrexate (MTX) cause serious lung diseases such as pulmonary fibrosis. Although evidences showing the association of epithelial-mesenchymal transition (EMT) with pulmonary fibrosis are increasing, the mechanism underlying anticance...

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Bibliographic Details
Main Authors: Ayano Yamamoto, Masashi Kawami, Takashi Konaka, Shinnosuke Takenaka, Ryoko Yumoto, Mikihisa Takano
Format: Article
Language:English
Published: Canadian Society for Pharmaceutical Sciences 2019-10-01
Series:Journal of Pharmacy & Pharmaceutical Sciences
Online Access:https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/30660