DNA Repair Syndromes and Cancer: Insights Into Genetics and Phenotype Patterns

DNA Repair Syndromes and Cancer: Insights Into Genetics and Phenotype Patterns

DNA damage response is essential to human physiology. A broad spectrum of pathologies are displayed by individuals carrying monoallelic or biallelic loss-of-function mutations in DNA damage repair genes. DNA repair syndromes with biallelic disturbance of essential DNA damage response pathways manife...

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Bibliographic Details
Main Authors: Richa Sharma, Sara Lewis, Marcin W. Wlodarski
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Pediatrics
Subjects:
DNA repair
cancer predisposition
hematological malignances
hereditary cancer
pediatric cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2020.570084/full

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