Pharmacological activation of the EDA/EDAR signaling pathway restores salivary gland function following radiation-induced damage.

Pharmacological activation of the EDA/EDAR signaling pathway restores salivary gland function following radiation-induced damage.

Radiotherapy of head and neck cancers often results in collateral damage to adjacent salivary glands associated with clinically significant hyposalivation and xerostomia. Due to the reduced capacity of salivary glands to regenerate, hyposalivation is treated by substitution with artificial saliva, r...

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Bibliographic Details
Main Authors: Grace Hill, Denis Headon, Zoey I Harris, Kenneth Huttner, Kirsten H Limesand
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4237357?pdf=render

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