Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels

Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels

Clonal dynamics of Barrett’s esophagus (BE) leading to cancer are poorly understood. Here, they report BE segments are clonal, have frequent mutations at the gastro-esophageal junction, genomic instability precedes genome doubling/clonal expansion, and a correlation between inter- and intra-biopsy g...

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Main Authors: Pierre Martinez, Diego Mallo, Thomas G. Paulson, Xiaohong Li, Carissa A. Sanchez, Brian J. Reid, Trevor A. Graham, Mary K. Kuhner, Carlo C. Maley
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02621-x
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spelling doaj-3f3cef910e5f438080a7e775be0b18832021-05-11T09:27:36ZengNature Publishing GroupNature Communications2041-17232018-02-019111210.1038/s41467-017-02621-xEvolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levelsPierre Martinez0Diego Mallo1Thomas G. Paulson2Xiaohong Li3Carissa A. Sanchez4Brian J. Reid5Trevor A. Graham6Mary K. Kuhner7Carlo C. Maley8Evolution and Cancer Laboratory, Barts Cancer Institute, Queen Mary University of London, Charterhouse SquareBiodesign Center for Personalized Diagnostics, Biodesign Institute, Arizona State UniversityDivisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research CenterDivisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research CenterDivisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research CenterDivisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research CenterEvolution and Cancer Laboratory, Barts Cancer Institute, Queen Mary University of London, Charterhouse SquareDepartment of Genome Sciences, University of WashingtonBiodesign Center for Personalized Diagnostics, Biodesign Institute, Arizona State UniversityClonal dynamics of Barrett’s esophagus (BE) leading to cancer are poorly understood. Here, they report BE segments are clonal, have frequent mutations at the gastro-esophageal junction, genomic instability precedes genome doubling/clonal expansion, and a correlation between inter- and intra-biopsy genetic diversity.https://doi.org/10.1038/s41467-017-02621-x
collection DOAJ
language English
format Article
sources DOAJ
author Pierre Martinez
Diego Mallo
Thomas G. Paulson
Xiaohong Li
Carissa A. Sanchez
Brian J. Reid
Trevor A. Graham
Mary K. Kuhner
Carlo C. Maley
spellingShingle Pierre Martinez
Diego Mallo
Thomas G. Paulson
Xiaohong Li
Carissa A. Sanchez
Brian J. Reid
Trevor A. Graham
Mary K. Kuhner
Carlo C. Maley
Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
Nature Communications
author_facet Pierre Martinez
Diego Mallo
Thomas G. Paulson
Xiaohong Li
Carissa A. Sanchez
Brian J. Reid
Trevor A. Graham
Mary K. Kuhner
Carlo C. Maley
author_sort Pierre Martinez
title Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
title_short Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
title_full Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
title_fullStr Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
title_full_unstemmed Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
title_sort evolution of barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-02-01
description Clonal dynamics of Barrett’s esophagus (BE) leading to cancer are poorly understood. Here, they report BE segments are clonal, have frequent mutations at the gastro-esophageal junction, genomic instability precedes genome doubling/clonal expansion, and a correlation between inter- and intra-biopsy genetic diversity.
url https://doi.org/10.1038/s41467-017-02621-x
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