ROLE OF INTERLEUKIN 1 IN THE DEVELOPMENT OF HUMAN DISEASES

• Main Authors: E. L. Nasonov, M. S. Eliseev
• Format: Article
• Language: Russian
• Published: IMA-PRESS LLC 2016-03-01
• Series: Научно-практическая ревматология
• Subjects: immunoinflammatory diseases; autoinflammatory diseases; cytokines; inflammasome; interleukin 1; interleukin 1 inhibitors
• Online Access: https://rsp.mediar-press.net/rsp/article/view/2171

According to the predominant mechanisms of immunity activation, human inflammatory diseases are divided into two main categories: autoimmune and autoinflammatory ones. At the same time, the autoimmune and autoinflammatory diseases have much common in both the range of clinical manifestations and trigger environmental, epigenetic, and genetic factors, inflammatory mediators, tissue damage, and approaches to pharmacotherapy. The hyperproduction of the proinflammatory cytokine interleukin 1 (IL-1) is supposed to largely determine the cross between autoimmunity and autoinflammation, which is characteristic of many immunoinflammatory diseases. The study of a role of IL-1 in regulating an interaction between innate (Toll-like receptor activation, inflammasomes) and adaptive (Th1 and Th17 immune responses) immunities and efficiency of IL-1 inhibitors may be of great importance in interpreting the pathogenetic mechanisms of human immunoinflammatory diseases and elaborating novel approaches to personified therapy.