Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy

Unlike canonical macroautophagy, alternative autophagy does not require the factors Atg5 and Atg7, but does require Ulk1. Here the authors show that phosphorylation of Ulk1 at Ser746 by RIPK3 is required for alternative autophagy initiation at the Golgi in response to genotoxic stress.

Bibliographic Details
Main Authors:	Satoru Torii, Hirofumi Yamaguchi, Akira Nakanishi, Satoko Arakawa, Shinya Honda, Kenta Moriwaki, Hiroyasu Nakano, Shigeomi Shimizu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15577-2

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spelling	doaj-3f3a5cabe5ec4005addc0c3f0c1db2512021-05-11T07:59:46ZengNature Publishing GroupNature Communications2041-17232020-04-0111111910.1038/s41467-020-15577-2Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagySatoru Torii0Hirofumi Yamaguchi1Akira Nakanishi2Satoko Arakawa3Shinya Honda4Kenta Moriwaki5Hiroyasu Nakano6Shigeomi Shimizu7Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU)Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU)Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University (TMDU)Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU)Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU)Department of Cell Biology, Graduate School of Medicine, Osaka UniversityDepartment of Biochemistry, Toho University School of MedicineDepartment of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU)Unlike canonical macroautophagy, alternative autophagy does not require the factors Atg5 and Atg7, but does require Ulk1. Here the authors show that phosphorylation of Ulk1 at Ser746 by RIPK3 is required for alternative autophagy initiation at the Golgi in response to genotoxic stress.https://doi.org/10.1038/s41467-020-15577-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Satoru Torii Hirofumi Yamaguchi Akira Nakanishi Satoko Arakawa Shinya Honda Kenta Moriwaki Hiroyasu Nakano Shigeomi Shimizu
spellingShingle	Satoru Torii Hirofumi Yamaguchi Akira Nakanishi Satoko Arakawa Shinya Honda Kenta Moriwaki Hiroyasu Nakano Shigeomi Shimizu Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy Nature Communications
author_facet	Satoru Torii Hirofumi Yamaguchi Akira Nakanishi Satoko Arakawa Shinya Honda Kenta Moriwaki Hiroyasu Nakano Shigeomi Shimizu
author_sort	Satoru Torii
title	Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy
title_short	Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy
title_full	Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy
title_fullStr	Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy
title_full_unstemmed	Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy
title_sort	identification of a phosphorylation site on ulk1 required for genotoxic stress-induced alternative autophagy
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-04-01
description	Unlike canonical macroautophagy, alternative autophagy does not require the factors Atg5 and Atg7, but does require Ulk1. Here the authors show that phosphorylation of Ulk1 at Ser746 by RIPK3 is required for alternative autophagy initiation at the Golgi in response to genotoxic stress.
url	https://doi.org/10.1038/s41467-020-15577-2
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Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy

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