Prd1 associates with the clathrin adaptor α-Adaptin and the kinesin-3 Imac/Unc-104 to govern dendrite pruning in Drosophila.

Prd1 associates with the clathrin adaptor α-Adaptin and the kinesin-3 Imac/Unc-104 to govern dendrite pruning in Drosophila.

Refinement of the nervous system depends on selective removal of excessive axons/dendrites, a process known as pruning. Drosophila ddaC sensory neurons prune their larval dendrites via endo-lysosomal degradation of the L1-type cell adhesion molecule (L1-CAM), Neuroglian (Nrg). Here, we have identifi...

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Bibliographic Details
Main Authors: Wenhui Zong, Yan Wang, Quan Tang, Heng Zhang, Fengwei Yu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-08-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC6126864?pdf=render

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