Identifying the assembly intermediate in which Gag first associates with unspliced HIV-1 RNA suggests a novel model for HIV-1 RNA packaging.

Identifying the assembly intermediate in which Gag first associates with unspliced HIV-1 RNA suggests a novel model for HIV-1 RNA packaging.

During immature capsid assembly, HIV-1 genome packaging is initiated when Gag first associates with unspliced HIV-1 RNA by a poorly understood process. Previously, we defined a pathway of sequential intracellular HIV-1 capsid assembly intermediates; here we sought to identify the intermediate in whi...

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Bibliographic Details
Main Authors: Brook C Barajas, Motoko Tanaka, Bridget A Robinson, Daryl J Phuong, Kasana Chutiraka, Jonathan C Reed, Jaisri R Lingappa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5940231?pdf=render

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http://europepmc.org/articles/PMC5940231?pdf=render

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