Pharmacokinetic Potentiation of Mixed Organophosphate and Pyrethroid Poison Leading to Prolonged Delayed Neuropathy
Organophosphate (OP) and mixed pesticide poisoning remains an important cause of hospital admission. Therefore, physician must be aware of atypical presentations of delayed neurological complications of poisoning by taking proper patient history. We report a case of a 23-year-old female who presen...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8773/22756_CE(RA1)_F(T)_PF1(AH_RK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Organophosphate (OP) and mixed pesticide poisoning remains an important cause of hospital admission. Therefore, physician must be
aware of atypical presentations of delayed neurological complications of poisoning by taking proper patient history. We report a case
of a 23-year-old female who presented with high stepping gait and muscle wasting in hands. Patient history revealed consumption of
approximately 4ml of mixed pesticide, consisting of 50% chlorpyrifos with synthetic pyrethroid, 5% cypermethrin. The prolonged and
severe nature of delayed peripheral neuropathy, persisting at two years of follow-up, suggests that even small quantities of OP taken in
combination with a pyrethroid can result in significant morbidity and is irreversible. |
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| ISSN: | 2249-782X 0973-709X |