Toxicokinetics of cotyledoside following intravenous administration to sheep

Cotyledoside, a bufadienolide cardiac glycoside, was administered intravenously to sheep in 2 studies. In experiment 1, sheep (n = 4) received 0.0135 mg / kg daily on 5 consecutive days and in the 2nd experiment, sheep (n = 4) received 0.027 mg / kg as a single dose. Jugular blood was collected at d...

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Bibliographic Details
Main Authors: C.J. Botha, T. Rundberget, G.E. Swan, M.S.G. Mulders, A. Flaoyen
Format: Article
Language:English
Published: AOSIS 2003-06-01
Series:Journal of the South African Veterinary Association
Subjects:
Online Access:https://jsava.co.za/index.php/jsava/article/view/488