A novel strategy for inducing enhanced mucosal HIV-1 antibody responses in an anti-inflammatory environment.

A novel strategy for inducing enhanced mucosal HIV-1 antibody responses in an anti-inflammatory environment.

Prophylactic vaccination against HIV-1 sexual transmission will probably require antibody elicitation at genital mucosal surfaces. However, HIV-1 envelope glycoprotein (Env)-based antigens are weakly immunogenic, particularly when applied mucosally. The polyanion PRO 2000 is safe for human vaginal a...

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Bibliographic Details
Main Authors: Frank Wegmann, George Krashias, Kerstin Lühn, Karoliina Laamanen, Sueli Vieira, Simon A Jeffs, Robin J Shattock, Quentin J Sattentau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3017049?pdf=render

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