Human spinal GABA neurons alleviate spasticity and improve locomotion in rats with spinal cord injury

Human spinal GABA neurons alleviate spasticity and improve locomotion in rats with spinal cord injury

Summary: Spinal cord injury (SCI) often results in spasticity. There is currently no effective therapy for spasticity. Here, we describe a method to efficiently differentiate human pluripotent stem cells from spinal GABA neurons. After transplantation into the injured rat spinal cord, the DREADD (de...

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Bibliographic Details
Main Authors: ChenZi Gong, Xiaolong Zheng, FangLiang Guo, YaNan Wang, Song Zhang, Jing Chen, XueJiao Sun, Sayed Zulfiqar Ali Shah, YiFeng Zheng, Xiao Li, Yatao Yin, Qian Li, XiaoLin Huang, Tiecheng Guo, Xiaohua Han, Su-Chun Zhang, Wei Wang, Hong Chen
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
spinal cord injury
human embryonic stem cell
human pluripotent stem cells
somatosensory GABA neurons
spasticity
DREADD
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002035

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