Targeting Interleukin(IL)-30/IL-27p28 signaling in cancer stem-like cells and host environment synergistically inhibits prostate cancer growth and improves survival

Targeting Interleukin(IL)-30/IL-27p28 signaling in cancer stem-like cells and host environment synergistically inhibits prostate cancer growth and improves survival

Abstract Background Interleukin(IL)-30/IL-27p28 production by Prostate Cancer (PC) Stem-Like Cells (SLCs) has proven, in murine models, to be critical to tumor onset and progression. In PC patients, IL-30 expression by leukocytes infiltrating PC and draining lymph nodes correlates with advanced dise...

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Bibliographic Details
Main Authors: Carlo Sorrentino, Zhinan Yin, Stefania Ciummo, Paola Lanuti, Li-Fan Lu, Marco Marchisio, Matteo Bellone, Emma Di Carlo
Format: Article
Language:English
Published: BMJ Publishing Group 2019-07-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Interleukin-30
Tumor microenvironment
Prostate Cancer Stem-Like Cells
Treg cells
Immunohistochemistry
Online Access:http://link.springer.com/article/10.1186/s40425-019-0668-z

Internet

http://link.springer.com/article/10.1186/s40425-019-0668-z

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