Experimental study of the protective effect of autoantibodies against the β3-adrenorceptor on heart function of rat model with heart failure

• Main Author: Yin-Wen Xia
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-02-01
• Series: Journal of Hainan Medical University
• Subjects: VAP; Gastroesophageal reflux; Pepsin; CPIS.
• Online Access: http://www.jhmuweb.net/PDF/201604/3.pdf

Objective: To explore the correlation of gastroesophageal reflux with ventilator-associated pneumonia (VAP). Methods: A total of 84 patients who were performed with mechanical assisted ventilation in our hospital were included in the study. The pharyngeal and tracheal secretions 2 d (T1), 4 d (T2), and 6 d (T3) after mechanical ventilation were collected, respectively. ELISA was used to detect the pepsin concentration. The clinical pulmonary infection score (CPIS) was performed to the patients in order to analyze the correlation of pepsin concentration with CPIS. Results: The positive rate of pharyngeal pepsin at T1 was 16.7%, at T2 was 54.8%, and at T3 was 78.6%. The positive rate of pepsin was increased with the extending of mechanical ventilation time. The comparison of pepsin concentration in the pharyngeal secretions at T1 between the VAP patients and non-VAP patients was not statistically significant, but the pepsin concentration in the tracheal secretions was significantly higher than that in the non-VAP patients. The pepsin concentration in the pharyngeal and tracheal secretions at T2 and T3 in the VAP patients was significantly higher than that in the non-VAP patients. The pepsin concentration in the tracheal secretions in the VAP patients was associated with CPIS. Conclusions: The positive rate of pepsin concentration in the pharyngeal and tracheal secretions in the VAP patients is increased with the extending of mechanical ventilation time. The positive rate of pepsin concentration in the tracheal secretions at each timing point in the VAP patients is significantly higher than that in the non-VAP patients. The pepsin concentration in the pharyngeal and tracheal secretions in the VAP patients is positively correlated with CPIS.