Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4

Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4

Abstract Background Evidence indicates a cross-regulation between two kinases, leucine-rich repeat kinase 2 (LRRK2) and protein kinase A (PKA). In neurons, LRRK2 negatively regulates PKA activity in spiny projecting neurons during synaptogenesis and in response to dopamine D1 receptor activation act...

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Bibliographic Details
Main Authors: Isabella Russo, Giulietta Di Benedetto, Alice Kaganovich, Jinhui Ding, Daniela Mercatelli, Michele Morari, Mark R. Cookson, Luigi Bubacco, Elisa Greggio
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Neuroinflammation
Subjects:
LRRK2
PKA
Microglia
Neuroinflammation
Parkinson’s disease
PDE4
Online Access:http://link.springer.com/article/10.1186/s12974-018-1337-8

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