| Summary: | Objective: To investigate variation of T lymphocyte subsets, inflammatory factors and
coagulation functional indexes at different stages for patients with pulmonary tuberculosis
and significance of discussion and treatment on mechanism of pulmonary tuberculosis.
Methods: 48 cases of patients with pulmonary tuberculosis at progressive stage treated in
our hospital were selected as the progression group, and 50 cases of patients with pulmonary
tuberculosis at remission stage were selected as the remission group. Meanwhile, 48 cases
of healthy population in our hospital were selected as the control group. Variations and
significances of T lymphocyte subsets (CD3+, CD4+, CD8+ and CD4+/CD8+), inflammatory
factors [interleukin-2 (IL-2), interleukin-10 (IL-10), interferon-γ (IFN-γ) and tumor necrosis
factor-α (TNF-α)] and coagulation function [Fg (fibrinogen), TT (thrombin time), PLT (platelet)
and D-D (D-dimer)] were analyzed. Results: Coagulation function (Fg, TT, PLT and D-D),
T lymphocyte subsets CD8+ and inflammatory factors (IL-2, IL-10 and TNF-α) in patients
with pulmonary tuberculosis in progression group were significantly higher than in healthy
population of control group (P<0.05). T lymphocyte subsets (CD3+, CD4+ andCD4+/CD8+)
and IFN-γ were significantly lower than in healthy population of control group (P<0.05).
Coagulation function (Fg, TT, PLT and D-D), T lymphocyte subsets CD8+ and inflammatory
factors (IL-2, IL-10 and TNF-α) in patients with pulmonary tuberculosis in remission group
were significantly lower than in patients of progression group (P<0.05), but significantly higher
than in healthy population of control group (P<0.05). T lymphocyte subsets (CD3+, CD4+ and
CD4+/CD8+) and IFN-γ in patients with pulmonary tuberculosis in remission group were
significantly higher than in patients of progression group (P<0.05), but significantly lower
than in healthy population of control group (P<0.05). Conclusions: Significant variations
appeared on T lymphocyte subsets, inflammatory factors and coagulation functional indexes at
different stages for patients with pulmonary tuberculosis, which had important significance on
discussion and treatment of pulmonary tuberculosis mechanism.
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