Synthesis of 1-Benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-Rstyryl)-2,3-dihydropyrazolo[3,4-b][1,4]diazepines

Synthesis of 1-Benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-Rstyryl)-2,3-dihydropyrazolo[3,4-b][1,4]diazepines

The reaction of 4-amino-5-benzylamino-3-(4-chlorophenyl)-1H-pyrazole (1) with substituted diarylidenketones (2) constitutes a convenient synthetic route to the hitherto unknown 1-benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-R-styryl)-2,3-dihydropyrazolo-[3,4-b][1,4]diazepines (3). Structures of all...

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Bibliographic Details
Main Authors: E. Angeles, Alfredo Toscano, Roberto Martínez, Rodrigo Abonía, Jairo Quiroga, Ricaurte Rodríguez, Braulio Insuasty
Format: Article
Language:English
Published: MDPI AG 2001-07-01
Series:Molecules
Subjects:
Diazepine derivatives
diarylidenketones
Online Access:http://www.mdpi.com/1420-3049/6/8/710/
Description
Summary:The reaction of 4-amino-5-benzylamino-3-(4-chlorophenyl)-1H-pyrazole (1) with substituted diarylidenketones (2) constitutes a convenient synthetic route to the hitherto unknown 1-benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-R-styryl)-2,3-dihydropyrazolo-[3,4-b][1,4]diazepines (3). Structures of all products were consistent with their IR, 1H-NMR, 13C-NMR and MS spectral data. X-ray crystallography data confirm the assigned structures.
ISSN:1420-3049

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