Proteomics in Vaccinology and Immunobiology: An Informatics Perspective of the Immunone
The postgenomic era, as manifest, inter alia, by proteomics, offers unparalleled opportunities for the efficient discovery of safe, efficacious, and novel subunit vaccines targeting a tranche of modern major diseases. A negative corollary of this opportunity is the risk of becoming overwhelmed by th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2003-01-01
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| Series: | Journal of Biomedicine and Biotechnology |
| Online Access: | http://dx.doi.org/10.1155/S1110724303209232 |
| Summary: | The postgenomic era, as manifest, inter alia, by proteomics,
offers unparalleled opportunities for the efficient discovery of
safe, efficacious, and novel subunit vaccines targeting a tranche
of modern major diseases. A negative corollary of this opportunity
is the risk of becoming overwhelmed by this embarrassment of
riches. Informatics techniques, working to address issues of both
data management and through prediction to shortcut the
experimental process, can be of enormous benefit in leveraging
the proteomic revolution. In this disquisition, we evaluate
proteomic approaches to the discovery of subunit vaccines,
focussing on viral, bacterial, fungal, and parasite systems. We
also adumbrate the impact that proteomic analysis of
host-pathogen interactions can have. Finally, we review relevant
methods to the prediction of immunome, with special emphasis on
quantitative methods, and the subcellular localization of
proteins within bacteria. |
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| ISSN: | 1110-7243 1110-7251 |