Loss of histone H3 methylation at lysine 4 triggers apoptosis in Saccharomyces cerevisiae.

Monoubiquitination of histone H2B lysine 123 regulates methylation of histone H3 lysine 4 (H3K4) and 79 (H3K79) and the lack of H2B ubiquitination in Saccharomyces cerevisiae coincides with metacaspase-dependent apoptosis. Here, we discovered that loss of H3K4 methylation due to depletion of the met...

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Bibliographic Details
Main Authors: David Walter, Anja Matter, Birthe Fahrenkrog
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3907299?pdf=render