Rational design of cyclopropane-based chiral PHOX ligands for intermolecular asymmetric Heck reaction

Rational design of cyclopropane-based chiral PHOX ligands for intermolecular asymmetric Heck reaction

A novel class of chiral phosphanyl-oxazoline (PHOX) ligands with a conformationally rigid cyclopropyl backbone was synthesized and tested in the intermolecular asymmetric Heck reaction. Mechanistic modelling and crystallographic studies were used to predict the optimal ligand structure and helped to...

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Bibliographic Details
Main Authors:	Marina Rubina, William M. Sherrill, Alexey Yu. Barkov, Michael Rubin
Format:	Article
Language:	English
Published:	Beilstein-Institut 2014-07-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	asymmetric catalysis chiral phosphine ligands cyclopropane Heck reaction organophosphorus transition metal catalysis
Online Access:	https://doi.org/10.3762/bjoc.10.158

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