MiR-421 Binds to PINK1 and Enhances Neural Stem Cell Self-Renewal via HDAC3-Dependent FOXO3 Activation

MiR-421 Binds to PINK1 and Enhances Neural Stem Cell Self-Renewal via HDAC3-Dependent FOXO3 Activation

Dysfunctions of neural stem cells (NSCs) often lead to a variety of neurological diseases. Thus, therapies based on NSCs have gained increasing attention recently. It has been documented that microRNA (miR)-421 represses the autophagy and apoptosis of mouse hippocampal neurons and confers a role in...

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Bibliographic Details
Main Authors: Jiaoying Jia, Ming Wang, Min Liu, Zhigang Tan, Yan Cui, Mengqiang Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
PINK1
HDAC3
FOXO3
neural stem cell
self-renewal
ischemic brain injury
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.621187/full

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