3-Hydroxybutyrate as a Metabolite and a Signal Molecule Regulating Processes of Living Organisms

• Main Authors: Justyna Mierziak, Marta Burgberger, Wioleta Wojtasik
• Format: Article
• Language: English
• Published: MDPI AG 2021-03-01
• Series: Biomolecules
• Subjects: 3-hydroxybutyrate; polyhydroxybutyrate; 3-HB metabolism; signaling; animals; bacteria
• Online Access: https://www.mdpi.com/2218-273X/11/3/402

3-hydroxybutyrate (3-HB) as a very important metabolite occurs in animals, bacteria and plants. It is well known that in animals, 3-HB is formed as a product of the normal metabolism of fatty acid oxidation and can therefore be used as an energy source in the absence of sufficient blood glucose. In microorganisms, 3-HB mainly serves as a substrate for the synthesis of polyhydroxybutyrate, which is a reserve material. Recent studies show that in plants, 3-HB acts as a regulatory molecule that most likely influences the expression of genes involved in DNA methylation, thereby altering DNA methylation levels. Additionally, in animals, 3-HB is not only an intermediate metabolite, but also an important regulatory molecule that can influence gene expression, lipid metabolism, neuronal function, and overall metabolic rate. Some of these effects are the direct effects of 3-HB itself, while others are indirect effects, regulated by the metabolites into which 3-HB is converted. One of the most important regulatory functions of 3-HB is the inhibition of the activity of histone deacetylases and thus the epigenetic regulation of many genes. Due to the number of functions of this compound, it also shows promising therapeutic properties.