Characterization of zolbetuximab in pancreatic cancer models

Characterization of zolbetuximab in pancreatic cancer models

In healthy tissue, the tight junction protein Claudin 18.2 (CLDN18.2) is present only in the gastric mucosa. Upon malignant transformation of gastric epithelial tissue, perturbations in cell polarity lead to cell surface exposure of CLDN18.2 epitopes. Moreover, CLDN18.2 is aberrantly expressed in ma...

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Bibliographic Details
Main Authors:	Ӧzlem Türeci, Rita Mitnacht-Kraus, Stefan Wöll, Tomohiro Yamada, Ugur Sahin
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2019-01-01
Series:	OncoImmunology
Subjects:	claudin 18.2 zolbetuximab imab362 monoclonal antibody targeted therapy pancreatic cancer antibody-dependent cellular cytotoxicity adcc complement-dependent cytotoxicity immunotherapy
Online Access:	http://dx.doi.org/10.1080/2162402X.2018.1523096

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