Growth hormone deficiency in cleft lip and palate patients

Introduction: Failure to thrive (FTT) is relatively common among cleft patients, most commonly attributed to feeding problems during the first months of life. Close association between midline clefts and pituitary gland abnormalities prompted us to determine the frequency of growth hormone deficienc...

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Main Authors: Shahin AbdollahiFakhim, Gholamreza Bayazian, Siamak Shiva, Mojtaba Sohrabpour, Younes Ebrahimzade
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2015-11-01
Series:Journal of Analytical Research in Clinical Medicine
Subjects:
Online Access:http://journals.tbzmed.ac.ir/JARCM/Manuscript/JARCM-3-231.pdf
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spelling doaj-3ec41247f94a4dfe97a2dd19c79a256a2020-11-24T21:43:36ZengTabriz University of Medical SciencesJournal of Analytical Research in Clinical Medicine2345-49702015-11-013423123510.15171/jarcm.2015.036JARCM_919_20141007093211Growth hormone deficiency in cleft lip and palate patientsShahin AbdollahiFakhim0Gholamreza Bayazian1Siamak Shiva2Mojtaba Sohrabpour3Younes Ebrahimzade4Associate Professor, Pediatric Research Center, Koodakan Hospital, Tabriz University of Medical Sciences, Tabriz, IranAssistant Professor, Hazrat Rasoul Hospital, Iran University of Medical Sciences, Tehran, IranAssociate Professor, Department of Pediatrics, School of Medicine, Koodakan Hospital, Tabriz University of Medical Sciences, Tabriz, IranResident, Department of Otolaryngology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, IranResident, Department of Otolaryngology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, IranIntroduction: Failure to thrive (FTT) is relatively common among cleft patients, most commonly attributed to feeding problems during the first months of life. Close association between midline clefts and pituitary gland abnormalities prompted us to determine the frequency of growth hormone deficiency in cleft patients, which is easily treated. Methods: Any cleft patient with FTT was studied and when the patient’s height was under the 3rd percentile of normal, growth hormone was checked after clonidine administration. Growth hormone was checked before and 30, 60 and 90 minutes after clonidine use. Results: Of 670 patients with cleft lip or palate, 31 patients (4%) had some kind of growth retardation according to weight, height or head circumstance. Eighteen patients were under the 3rd percentile of normal height. Growth hormone deficiency was detected in 8 patients out of 18 patients and overall frequency of growth hormone deficiency among cleft patients with growth retardation was 25.8% (8 out of 31). Seven patients of 8 were male whereas one was female and half of the patients were syndromic. Conclusion: Cleft patients have many problems with normal feeding and all kind of support should be provided to achieve near-normal feeding and they should be monitored for normal growth. Any patient with growth retardation, especially height decrease, should be assessed for growth hormone deficiency.http://journals.tbzmed.ac.ir/JARCM/Manuscript/JARCM-3-231.pdfCleft lipCleft palateGrowth hormone deficiencyFailure to thrive
collection DOAJ
language English
format Article
sources DOAJ
author Shahin AbdollahiFakhim
Gholamreza Bayazian
Siamak Shiva
Mojtaba Sohrabpour
Younes Ebrahimzade
spellingShingle Shahin AbdollahiFakhim
Gholamreza Bayazian
Siamak Shiva
Mojtaba Sohrabpour
Younes Ebrahimzade
Growth hormone deficiency in cleft lip and palate patients
Journal of Analytical Research in Clinical Medicine
Cleft lip
Cleft palate
Growth hormone deficiency
Failure to thrive
author_facet Shahin AbdollahiFakhim
Gholamreza Bayazian
Siamak Shiva
Mojtaba Sohrabpour
Younes Ebrahimzade
author_sort Shahin AbdollahiFakhim
title Growth hormone deficiency in cleft lip and palate patients
title_short Growth hormone deficiency in cleft lip and palate patients
title_full Growth hormone deficiency in cleft lip and palate patients
title_fullStr Growth hormone deficiency in cleft lip and palate patients
title_full_unstemmed Growth hormone deficiency in cleft lip and palate patients
title_sort growth hormone deficiency in cleft lip and palate patients
publisher Tabriz University of Medical Sciences
series Journal of Analytical Research in Clinical Medicine
issn 2345-4970
publishDate 2015-11-01
description Introduction: Failure to thrive (FTT) is relatively common among cleft patients, most commonly attributed to feeding problems during the first months of life. Close association between midline clefts and pituitary gland abnormalities prompted us to determine the frequency of growth hormone deficiency in cleft patients, which is easily treated. Methods: Any cleft patient with FTT was studied and when the patient’s height was under the 3rd percentile of normal, growth hormone was checked after clonidine administration. Growth hormone was checked before and 30, 60 and 90 minutes after clonidine use. Results: Of 670 patients with cleft lip or palate, 31 patients (4%) had some kind of growth retardation according to weight, height or head circumstance. Eighteen patients were under the 3rd percentile of normal height. Growth hormone deficiency was detected in 8 patients out of 18 patients and overall frequency of growth hormone deficiency among cleft patients with growth retardation was 25.8% (8 out of 31). Seven patients of 8 were male whereas one was female and half of the patients were syndromic. Conclusion: Cleft patients have many problems with normal feeding and all kind of support should be provided to achieve near-normal feeding and they should be monitored for normal growth. Any patient with growth retardation, especially height decrease, should be assessed for growth hormone deficiency.
topic Cleft lip
Cleft palate
Growth hormone deficiency
Failure to thrive
url http://journals.tbzmed.ac.ir/JARCM/Manuscript/JARCM-3-231.pdf
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