Intelligent H2S release coating for regulating vascular remodeling

Intelligent H2S release coating for regulating vascular remodeling

Coronary atherosclerotic lesions exhibit a low-pH chronic inflammatory response. Due to insufficient drug release control, drug-eluting stent intervention can lead to delayed endothelialization, advanced thrombosis, and unprecise treatment. In this study, hyaluronic acid and chitosan were used to pr...

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Main Authors: Bingyang Lu, Xiao Han, Ansha Zhao, Dan Luo, Manfred F. Maitz, Haohao Wang, Ping Yang, Nan Huang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-04-01
Series:Bioactive Materials
Subjects:
pH responsive
Layer-by-layer self-assembly film
H2S
Coronary atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X20302437
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spelling doaj-3eba229f738e4e5ea4896bb7e13ae4cc2021-02-07T04:24:16ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2021-04-016410401050Intelligent H2S release coating for regulating vascular remodelingBingyang Lu0Xiao Han1Ansha Zhao2Dan Luo3Manfred F. Maitz4Haohao Wang5Ping Yang6Nan Huang7Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China; Corresponding author. Key Lab. for Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, PR China.Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, ChinaLeibniz-Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials Dresden, Hohe Strasse 6, 01069, Dresden, GermanyKey Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, ChinaCoronary atherosclerotic lesions exhibit a low-pH chronic inflammatory response. Due to insufficient drug release control, drug-eluting stent intervention can lead to delayed endothelialization, advanced thrombosis, and unprecise treatment. In this study, hyaluronic acid and chitosan were used to prepare pH-responsive self-assembling films. The hydrogen sulfide (H2S) releasing aspirin derivative ACS14 was used as drug in the film. The film regulates the release of the drug adjusted to the microenvironment of the lesion, and the drug balances the vascular function by releasing the regulating gas H2S, which comparably to NO promotes the self-healing capacity of blood vessels. Drug releasing profiles of the films at different pH, and other biological effects on blood vessels were evaluated through blood compatibility, cellular, and implantation experiments. This novel method of self-assembled films which H2S in an amount, which is adjusted to the condition of the lesion provides a new concept for the treatment of cardiovascular diseases.http://www.sciencedirect.com/science/article/pii/S2452199X20302437pH responsiveLayer-by-layer self-assembly filmH2SCoronary atherosclerosis
collection DOAJ
language English
format Article
sources DOAJ
author Bingyang Lu
Xiao Han
Ansha Zhao
Dan Luo
Manfred F. Maitz
Haohao Wang
Ping Yang
Nan Huang
spellingShingle Bingyang Lu
Xiao Han
Ansha Zhao
Dan Luo
Manfred F. Maitz
Haohao Wang
Ping Yang
Nan Huang
Intelligent H2S release coating for regulating vascular remodeling
Bioactive Materials
pH responsive
Layer-by-layer self-assembly film
H2S
Coronary atherosclerosis
author_facet Bingyang Lu
Xiao Han
Ansha Zhao
Dan Luo
Manfred F. Maitz
Haohao Wang
Ping Yang
Nan Huang
author_sort Bingyang Lu
title Intelligent H2S release coating for regulating vascular remodeling
title_short Intelligent H2S release coating for regulating vascular remodeling
title_full Intelligent H2S release coating for regulating vascular remodeling
title_fullStr Intelligent H2S release coating for regulating vascular remodeling
title_full_unstemmed Intelligent H2S release coating for regulating vascular remodeling
title_sort intelligent h2s release coating for regulating vascular remodeling
publisher KeAi Communications Co., Ltd.
series Bioactive Materials
issn 2452-199X
publishDate 2021-04-01
description Coronary atherosclerotic lesions exhibit a low-pH chronic inflammatory response. Due to insufficient drug release control, drug-eluting stent intervention can lead to delayed endothelialization, advanced thrombosis, and unprecise treatment. In this study, hyaluronic acid and chitosan were used to prepare pH-responsive self-assembling films. The hydrogen sulfide (H2S) releasing aspirin derivative ACS14 was used as drug in the film. The film regulates the release of the drug adjusted to the microenvironment of the lesion, and the drug balances the vascular function by releasing the regulating gas H2S, which comparably to NO promotes the self-healing capacity of blood vessels. Drug releasing profiles of the films at different pH, and other biological effects on blood vessels were evaluated through blood compatibility, cellular, and implantation experiments. This novel method of self-assembled films which H2S in an amount, which is adjusted to the condition of the lesion provides a new concept for the treatment of cardiovascular diseases.
topic pH responsive
Layer-by-layer self-assembly film
H2S
Coronary atherosclerosis
url http://www.sciencedirect.com/science/article/pii/S2452199X20302437
work_keys_str_mv AT bingyanglu intelligenth2sreleasecoatingforregulatingvascularremodeling
AT xiaohan intelligenth2sreleasecoatingforregulatingvascularremodeling
AT anshazhao intelligenth2sreleasecoatingforregulatingvascularremodeling
AT danluo intelligenth2sreleasecoatingforregulatingvascularremodeling
AT manfredfmaitz intelligenth2sreleasecoatingforregulatingvascularremodeling
AT haohaowang intelligenth2sreleasecoatingforregulatingvascularremodeling
AT pingyang intelligenth2sreleasecoatingforregulatingvascularremodeling
AT nanhuang intelligenth2sreleasecoatingforregulatingvascularremodeling
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