Concurrent detection of cabozantinib as an anticancer agent and its major metabolites in human serum using fluorescence-coupled micellar liquid chromatography

Concurrent detection of cabozantinib as an anticancer agent and its major metabolites in human serum using fluorescence-coupled micellar liquid chromatography

A novel, highly sensitive, simple, and rapid strategy was designed and developed for simultaneous determination of cabozantinib (CBZ) as an anticancer agent and its main metabolites including monohydroxy sulfate (EXEL-1646), N-oxide (EXEL-5162(, amide cleavage product (EXEL-5366), and 6-desmethyl am...

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Bibliographic Details
Main Authors:	Xiurong Qi, Shuping Zhang, Mei Yu, Suliman Khan
Format:	Article
Language:	English
Published:	Elsevier 2021-07-01
Series:	Arabian Journal of Chemistry
Subjects:	Cabozantinib Metabolites Micellar chromatography Fluorescence detection Cetyltrimethylammonium bromid
Online Access:	http://www.sciencedirect.com/science/article/pii/S1878535221002215

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