Transglutaminase 2 protects against ischemic stroke

Transglutaminase 2 protects against ischemic stroke

Transglutaminase 2 (TG2) is a multifunctional protein that modulates cell survival and death pathways. It is upregulated in numerous ischemic models, and protects primary neurons from oxygen and glucose deprivation. TG2 binds to the hypoxia inducible factor (HIF) 1β and decreases the upregulation of...

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Bibliographic Details
Main Authors: A.J. Filiano, J. Tucholski, P.J. Dolan, G. Colak, G.V.W. Johnson
Format: Article
Language:English
Published: Elsevier 2010-09-01
Series:Neurobiology of Disease
Subjects:
Transglutaminase 2
Stroke
Ischemia
Hypoxia
Hypoxia inducible factor
Neuron
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110001348

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