RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix

RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix

It is unclear what regulates the fate of mesenchymal stem cells (MSCs) in arterial repair following injury. Here, the authors show that MSC differentiation following injury is triggered by RhoA which in turn stimulates the release of connective tissue growth factor and vascular endothelial growth fa...

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Main Authors: Changjun Li, Gehua Zhen, Yu Chai, Liang Xie, Janet L. Crane, Emily Farber, Charles R. Farber, Xianghang Luo, Peisong Gao, Xu Cao, Mei Wan
Format: Article
Language:English
Published: Nature Publishing Group 2016-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11455
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spelling doaj-3eb49847a740494ba08e8723147d5be32021-05-11T10:46:31ZengNature Publishing GroupNature Communications2041-17232016-04-017111510.1038/ncomms11455RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrixChangjun Li0Gehua Zhen1Yu Chai2Liang Xie3Janet L. Crane4Emily Farber5Charles R. Farber6Xianghang Luo7Peisong Gao8Xu Cao9Mei Wan10Department of Orthopaedic Surgery, Johns Hopkins University School of MedicineDepartment of Orthopaedic Surgery, Johns Hopkins University School of MedicineDepartment of Orthopaedic Surgery, Johns Hopkins University School of MedicineDepartment of Orthopaedic Surgery, Johns Hopkins University School of MedicineDepartment of Orthopaedic Surgery, Johns Hopkins University School of MedicineDepartment of Public Health Sciences, Center for Public Health Genomics, University of VirginiaDepartment of Public Health Sciences, Center for Public Health Genomics, University of VirginiaDepartment of Endocrinology, Institute of Endocrinology and Metabolism, Second Xiangya Hospital of Central South UniversityDepartment of Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of MedicineDepartment of Orthopaedic Surgery, Johns Hopkins University School of MedicineDepartment of Orthopaedic Surgery, Johns Hopkins University School of MedicineIt is unclear what regulates the fate of mesenchymal stem cells (MSCs) in arterial repair following injury. Here, the authors show that MSC differentiation following injury is triggered by RhoA which in turn stimulates the release of connective tissue growth factor and vascular endothelial growth factor.https://doi.org/10.1038/ncomms11455
collection DOAJ
language English
format Article
sources DOAJ
author Changjun Li
Gehua Zhen
Yu Chai
Liang Xie
Janet L. Crane
Emily Farber
Charles R. Farber
Xianghang Luo
Peisong Gao
Xu Cao
Mei Wan
spellingShingle Changjun Li
Gehua Zhen
Yu Chai
Liang Xie
Janet L. Crane
Emily Farber
Charles R. Farber
Xianghang Luo
Peisong Gao
Xu Cao
Mei Wan
RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix
Nature Communications
author_facet Changjun Li
Gehua Zhen
Yu Chai
Liang Xie
Janet L. Crane
Emily Farber
Charles R. Farber
Xianghang Luo
Peisong Gao
Xu Cao
Mei Wan
author_sort Changjun Li
title RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix
title_short RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix
title_full RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix
title_fullStr RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix
title_full_unstemmed RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF–VEGF complex in extracellular matrix
title_sort rhoa determines lineage fate of mesenchymal stem cells by modulating ctgf–vegf complex in extracellular matrix
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-04-01
description It is unclear what regulates the fate of mesenchymal stem cells (MSCs) in arterial repair following injury. Here, the authors show that MSC differentiation following injury is triggered by RhoA which in turn stimulates the release of connective tissue growth factor and vascular endothelial growth factor.
url https://doi.org/10.1038/ncomms11455
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AT yuchai rhoadetermineslineagefateofmesenchymalstemcellsbymodulatingctgfvegfcomplexinextracellularmatrix
AT liangxie rhoadetermineslineagefateofmesenchymalstemcellsbymodulatingctgfvegfcomplexinextracellularmatrix
AT janetlcrane rhoadetermineslineagefateofmesenchymalstemcellsbymodulatingctgfvegfcomplexinextracellularmatrix
AT emilyfarber rhoadetermineslineagefateofmesenchymalstemcellsbymodulatingctgfvegfcomplexinextracellularmatrix
AT charlesrfarber rhoadetermineslineagefateofmesenchymalstemcellsbymodulatingctgfvegfcomplexinextracellularmatrix
AT xianghangluo rhoadetermineslineagefateofmesenchymalstemcellsbymodulatingctgfvegfcomplexinextracellularmatrix
AT peisonggao rhoadetermineslineagefateofmesenchymalstemcellsbymodulatingctgfvegfcomplexinextracellularmatrix
AT xucao rhoadetermineslineagefateofmesenchymalstemcellsbymodulatingctgfvegfcomplexinextracellularmatrix
AT meiwan rhoadetermineslineagefateofmesenchymalstemcellsbymodulatingctgfvegfcomplexinextracellularmatrix
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