Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans

Current methods for on-chip glycan biosynthesis suffer from analysing products, often resulting in poor purity and yield. Here the authors report a glycan chip developed by introducing a pH-responsive i-motif DNA linker to control the immobilization and isolation of glycans on chips.

Bibliographic Details
Main Authors:	Hye Ryoung Heo, Kye Il Joo, Jeong Hyun Seo, Chang Sup Kim, Hyung Joon Cha
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-21538-0

id	doaj-3eb2ecbd5a8b4c19b5c913abf739dbae
record_format	Article
spelling	doaj-3eb2ecbd5a8b4c19b5c913abf739dbae2021-03-11T11:33:45ZengNature Publishing GroupNature Communications2041-17232021-03-0112111110.1038/s41467-021-21538-0Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycansHye Ryoung Heo0Kye Il Joo1Jeong Hyun Seo2Chang Sup Kim3Hyung Joon Cha4School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and TechnologyDepartment of Chemical Engineering, Pohang University of Science and TechnologySchool of Chemical Engineering, Yeungnam UniversitySchool of Chemistry and Biochemistry, Yeungnam UniversityDepartment of Chemical Engineering, Pohang University of Science and TechnologyCurrent methods for on-chip glycan biosynthesis suffer from analysing products, often resulting in poor purity and yield. Here the authors report a glycan chip developed by introducing a pH-responsive i-motif DNA linker to control the immobilization and isolation of glycans on chips.https://doi.org/10.1038/s41467-021-21538-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hye Ryoung Heo Kye Il Joo Jeong Hyun Seo Chang Sup Kim Hyung Joon Cha
spellingShingle	Hye Ryoung Heo Kye Il Joo Jeong Hyun Seo Chang Sup Kim Hyung Joon Cha Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans Nature Communications
author_facet	Hye Ryoung Heo Kye Il Joo Jeong Hyun Seo Chang Sup Kim Hyung Joon Cha
author_sort	Hye Ryoung Heo
title	Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans
title_short	Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans
title_full	Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans
title_fullStr	Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans
title_full_unstemmed	Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans
title_sort	glycan chip based on structure-switchable dna linker for on-chip biosynthesis of cancer-associated complex glycans
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-03-01
description	Current methods for on-chip glycan biosynthesis suffer from analysing products, often resulting in poor purity and yield. Here the authors report a glycan chip developed by introducing a pH-responsive i-motif DNA linker to control the immobilization and isolation of glycans on chips.
url	https://doi.org/10.1038/s41467-021-21538-0
work_keys_str_mv	AT hyeryoungheo glycanchipbasedonstructureswitchablednalinkerforonchipbiosynthesisofcancerassociatedcomplexglycans AT kyeiljoo glycanchipbasedonstructureswitchablednalinkerforonchipbiosynthesisofcancerassociatedcomplexglycans AT jeonghyunseo glycanchipbasedonstructureswitchablednalinkerforonchipbiosynthesisofcancerassociatedcomplexglycans AT changsupkim glycanchipbasedonstructureswitchablednalinkerforonchipbiosynthesisofcancerassociatedcomplexglycans AT hyungjooncha glycanchipbasedonstructureswitchablednalinkerforonchipbiosynthesisofcancerassociatedcomplexglycans
_version_	1724225371864301568

Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans

Similar Items