Markers of Mitochondrial Metabolism in Tumor Hypoxia, Systemic Inflammation, and Adverse Outcome of Rectal Cancer

Markers of Mitochondrial Metabolism in Tumor Hypoxia, Systemic Inflammation, and Adverse Outcome of Rectal Cancer

Tumor hypoxia contributes to therapy resistance and metastatic progression of locally advanced rectal cancer (LARC). We postulated that the tumor mitochondrial metabolism, manifested by reactive oxygen species (ROS) and mitochondrial DNA (mtDNA) damage, reflects how hypoxic conditions connect to can...

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Bibliographic Details
Main Authors: Paula A. Bousquet, Sebastian Meltzer, Linda Sønstevold, Ying Esbensen, Svein Dueland, Kjersti Flatmark, Beathe Sitter, Tone Frost Bathen, Therese Seierstad, Kathrine Røe Redalen, Lars Eide, Anne Hansen Ree
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523318302572

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