Cotinine and 6-Hydroxy-L-Nicotine Reverses Memory Deficits and Reduces Oxidative Stress in Aβ<sub>25-35</sub>-Induced Rat Model of Alzheimer’s Disease

Cotinine and 6-Hydroxy-L-Nicotine Reverses Memory Deficits and Reduces Oxidative Stress in Aβ<sub>25-35</sub>-Induced Rat Model of Alzheimer’s Disease

The nicotinic derivatives, cotinine (COT), and 6-hydroxy-L-nicotine (6HLN), showed promising cognitive-improving effects without exhibiting the nicotine’s side-effects. Here, we investigated the impact of COT and 6HLN on memory impairment and the oxidative stress in the Aβ<sub>25-35</sub>...

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Bibliographic Details
Main Authors: Razvan Stefan Boiangiu, Marius Mihasan, Dragos Lucian Gorgan, Bogdan Alexandru Stache, Brindusa Alina Petre, Lucian Hritcu
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Antioxidants
Subjects:
Alzheimer’s disease
nicotine
cotinine
6-hydroxy-L-nicotine
Aβ<sub>25-35</sub> peptide
memory
Online Access:https://www.mdpi.com/2076-3921/9/8/768

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