Intranasal Delivery of Inactivated Influenza Virus and Poly(I:C) Adsorbed Corn-Based Nanoparticle Vaccine Elicited Robust Antigen-Specific Cell-Mediated Immune Responses in Maternal Antibody Positive Nursery Pigs

Intranasal Delivery of Inactivated Influenza Virus and Poly(I:C) Adsorbed Corn-Based Nanoparticle Vaccine Elicited Robust Antigen-Specific Cell-Mediated Immune Responses in Maternal Antibody Positive Nursery Pigs

We designed the killed swine influenza A virus (SwIAV) H1N2 antigen (KAg) with polyriboinosinic:polyribocytidylic acid [(Poly(I:C)] adsorbed corn-derived Nano-11 particle based nanovaccine called Nano-11-KAg+Poly(I:C), and evaluated its immune correlates in maternally derived antibody (MDA)-positive...

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Bibliographic Details
Main Authors: Veerupaxagouda Patil, Sankar Renu, Ninoshkaly Feliciano-Ruiz, Yi Han, Anikethana Ramesh, Jennifer Schrock, Santosh Dhakal, Harm HogenEsch, Gourapura J. Renukaradhya
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
inactivated SwIAV
corn-based nanovaccine
cross-protective cell meditated immunity
polyfunctional T cells
maternal antibody
Poly(I:C)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.596964/full

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