Radiation unlocks the therapeutic potential of immune checkpoint blockers in lung cancer patients

Radiation unlocks the therapeutic potential of immune checkpoint blockers in lung cancer patients

CTLA4 blockers have limited activity in patients with chemorefractory lung cancer. Recent clinical data demonstrate that radiation therapy combined with CTLA4 blockers enables disease control in a sizeable fraction of these patients, correlating with increased circulating levels of type I interferon...

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Bibliographic Details
Main Authors: Eric C. Ko, Lorenzo Galluzzi
Format: Article
Language:English
Published: Taylor & Francis Group 2019-08-01
Series:OncoImmunology
Subjects:
cgas
ipilimumab
non-small cell lung carcinoma
sting
trex1
type i interferon
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1606624
Description
Summary:CTLA4 blockers have limited activity in patients with chemorefractory lung cancer. Recent clinical data demonstrate that radiation therapy combined with CTLA4 blockers enables disease control in a sizeable fraction of these patients, correlating with increased circulating levels of type I interferon and dynamic changes in the peripheral T cell repertoire.
ISSN:2162-402X

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